Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of the ISOLD Score (Interleukin Score for IntraOcular Lymphoma Diagnosis) in the Diagnosis of Vitreoretinal Lymphoma in Clinical Practice.

American journal of ophthalmology·2026
Same author

Challenges and future directions of AIRR-seq-based diagnostics.

Immunoinformatics (Amsterdam, Netherlands)·2026
Same author

Prognostic value of combined baseline FDG PET/CT radiomic parameters in primary mediastinal B-cell lymphoma.

Blood advances·2026
Same author

<i>Tet2</i> deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the <i>Nfkbia</i>-c-Rel axis.

HemaSphere·2026
Same author

REL overexpression and sustained NF-κB signaling associated with 2p gain induce resistance to BTK inhibitors in Chronic Lymphocytic Leukemia.

Leukemia·2025
Same author

Waldenström's macroglobulinemia: The LYSA pragmatic guidelines.

European journal of cancer (Oxford, England : 1990)·2025

Related Experiment Video

Updated: Mar 6, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.5K

Hepatitis C virus - Associated marginal zone lymphoma.

Marine Armand1, Caroline Besson2, Olivier Hermine3

  • 1Department of Hematology, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France; UPMC Univ Paris 06, UMRS-1138, Paris, France.

Best Practice & Research. Clinical Haematology
|March 15, 2017
PubMed
Summary

Hepatitis C virus (HCV) infection is linked to B-cell non-Hodgkin lymphoma, particularly marginal zone lymphoma (MZL) and diffuse large B-cell lymphoma (DLBCL). Antiviral treatment can lead to lymphoma regression, highlighting the virus's role in cancer development.

Keywords:
Hepatitis C virusLymphomagenesisMarginal zone lymphomaTreatment

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K
Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

13.4K

Related Experiment Videos

Last Updated: Mar 6, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.5K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K
Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

13.4K

Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • The association between Hepatitis C Virus (HCV) infection and B-cell non-Hodgkin lymphoma (NHL) is well-established.
  • Epidemiological studies and observed lymphoma regression post-HCV eradication support this link.
  • Marginal Zone Lymphoma (MZL) and Diffuse Large B-cell Lymphoma (DLBCL) are the most frequently observed subtypes.

Purpose of the Study:

  • To elucidate the role of HCV in lymphomagenesis.
  • To explore proposed mechanisms linking HCV to lymphoma development.
  • To assess the efficacy of antiviral therapy in treating HCV-associated lymphomas.

Main Methods:

  • Review of epidemiological studies.
  • Observation of lymphoma regression following antiviral treatment.
  • Analysis of proposed pathogenetic mechanisms.

Main Results:

  • HCV infection is a significant risk factor for developing MZL and DLBCL.
  • Lymphoma regression is observed after successful HCV eradication.
  • Proposed mechanisms include chronic B-cell receptor stimulation and direct viral protein effects.

Conclusions:

  • Antiviral therapy, especially direct-acting antiviral agents, is effective and safe for treating HCV-associated MZL.
  • Understanding HCV's role in lymphomagenesis is crucial for targeted treatment strategies.
  • Further research into viral-host interactions can refine therapeutic approaches for HCV-related lymphomas.