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Antibody reactivity with Skinner HSV vaccine
E M Muniu1, J Durham, D Shariff
1Department of Medical Microbiology, Medical School, University of Birmingham, UK.
Medical Microbiology and Immunology
|January 1, 1987
Abstract:
Antibody reactivity against herpes simplex virus (HSV) was investigated in 15 subjects who received three subcutaneous immunisations with Skinner HSV vaccine. Humoral antibody responses were detected against type 1 HSV in every subject and against type 2 HSV in all but one subject; immuno-precipitating antibody responses were infrequently detected. There was no antibody reactivity against host-cell (MRC-5), foetal calf serum or rubella virus antigen. None of the vaccinated subjects developed clinical evidence of herpes genitalis.