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Related Concept Videos

Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

98
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
98
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

55
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
55
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

76
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
76
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

74
Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
74
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

65
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
65
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

56
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
56

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Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
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Design, Implementation, and Assessment Approaches Within a Pharmacogenomics Course.

Connie M Remsberg1, Brenda S Bray1, Susan K Wright1

  • 1Washington State University Health Sciences, Spokane, Washington.

American Journal of Pharmaceutical Education
|March 15, 2017
PubMed
Summary

A new pharmacogenomics course enhanced student pharmacists' knowledge and skills in analyzing genomic data for clinical practice. Participation boosted their confidence in applying pharmacogenomics, improving patient care potential.

Keywords:
assessmentgenomic testingpharmacogeneticspharmacogenomicspharmacy curriculum

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Area of Science:

  • Pharmacogenomics
  • Genomic Education
  • Clinical Pharmacy

Background:

  • Pharmacogenomics is crucial for personalized medicine.
  • Integrating pharmacogenomic data into clinical practice requires specialized training.
  • Current educational approaches may not fully equip future pharmacists.

Purpose of the Study:

  • To design and implement a pharmacogenomics course.
  • To focus on analyzing and integrating pharmacogenomic data into clinical practice.
  • To assess the impact of the course on student self-confidence.

Main Methods:

  • A three-module course: didactic sessions, laboratory exercises (including self-genotyping), and clinical case studies.
  • Learning assessed via knowledge/application tests and a group project.
  • Course effectiveness evaluated through test performance, pre/post self-assessments, project, and course evaluations.

Main Results:

  • Student pharmacists demonstrated competency in pharmacogenomics knowledge.
  • Students successfully applied learned skills in clinical scenarios.
  • Participants reported increased confidence in analyzing genomic test results.

Conclusions:

  • The designed pharmacogenomics course effectively enhanced student learning.
  • The course positively influenced student self-confidence in pharmacogenomics.
  • This educational model can improve the integration of pharmacogenomics into clinical practice.