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Updated: Mar 6, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Very late transcatheter heart valve thrombosis
Etienne L Couture1, Serge Lepage1, Jean-Bernard Masson1
1Etienne L Couture, Serge Lepage, Benoit Daneault, Division of Cardiology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke J1H 5N4, Canada.
Abstract:
We describe a case of very late transcatheter heart valve (THV) thrombosis of a first-generation SAPIEN prosthesis (Edwards Lifesciences, Irvine, CA) implanted in a 64-year-old woman with severe symptomatic aortic stenosis. More than 54 mo after implantation, she presented with severe symptomatic prosthesis dysfunction (stenosis) which was successfully treated with oral anticoagulation. To our knowledge, this is the tardiest case of THV thrombosis ever reported. This case should increase clinical awareness for THV thrombosis even beyond the first two-year period following implantation.
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