Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A novel comprehensive opiate-receptor model.

V M Kolb1, J P Snyder

  • 1Department of Chemistry, University of Wisconsin-Parkside, Kenosha 53141.

NIDA Research Monograph
|January 1, 1986
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

β-1 tubulin R307H SNP alters microtubule dynamics and affects severity of a hereditary thrombocytopenia.

Journal of thrombosis and haemostasis : JTH·2014
Same author

Synthesis and pharmacological characterization of fluorescent opioid receptor probes.

Pharmaceutical research·2013
Same author

Prolonged receptor blockade by opioid receptor probes.

Pharmaceutical research·2013
Same author

Transport spectroscopy of single Pt impurities in silicon using Schottky barrier MOSFETs.

Journal of physics. Condensed matter : an Institute of Physics journal·2011
Same author

The problem of foreign botanicals.

Bulletin. American Pharmaceutical Association. Committee on National Formulary·2010
Same author

A stable dirhodium tetracarboxylate carbenoid: crystal structure, bonding analysis, and catalysis.

Journal of the American Chemical Society·2001

A novel opiate-receptor model explains molecular events, including agonist/antagonist actions and long-lasting effects. This computational approach enhances understanding of drug interactions at the molecular level.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Computational Chemistry

Background:

  • Opiate receptors are crucial targets for pain management and addiction therapies.
  • Existing models often lack comprehensive molecular-level detail.
  • Understanding receptor binding mechanisms is key to developing safer and more effective analgesics.

Purpose of the Study:

  • To propose a new, comprehensive opiate-receptor model.
  • To elucidate molecular events governing opiate receptor interactions.
  • To incorporate agonist/antagonist activity, ultra-long duration, and N-dealkylation into the model.

Main Methods:

  • Development of a computational model based on molecular-level event calculations.
  • Integration of key pharmacological parameters into the model.

Related Experiment Videos

  • Simulation of receptor binding dynamics.

    • Main Results:

    • The proposed model successfully integrates agonist versus antagonist actions.
    • It accounts for ultra-long-lasting activity observed with certain opiate compounds.
    • The model includes N-dealkylation processes occurring during receptor binding.

    Conclusions:

    • This comprehensive opiate-receptor model provides a deeper molecular understanding of drug-receptor interactions.
    • The model serves as a valuable tool for predicting pharmacological activity and designing novel therapeutics.
    • It offers insights into the mechanisms underlying prolonged opiate effects and metabolic transformations.