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Effect of chronic exercise on beta-endorphin receptor levels in rats
R A Houghten1, S M Pratt, E A Young
1Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.
NIDA Research Monograph
|January 1, 1986
Abstract:
A radioreceptor assay using [3H]2-beta-endorphin (B-EP) was used to examine binding in the brains of rats that had been exercised on a treadmill for 5 months. The binding of [3H]2-beta-EP to brain homogenates gave an average Kd of 0.830 +/- 0.055 nM for the controls and 0.826 + 0.022 nM for the runners, and respective Bmax's of 166 +/- 20 pM and 159 +/- 27 pM.