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Published on: January 2, 2013
Micro-emultocrit technique: A valuable tool for determination of critical HLB value of emulsions
Janus P F Macedo1, Leonardo L Fernandes1, Fábio R Formiga1
1Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
Abstract:
The aim of this work was to develop a methodology for rapid determination of the critical hydrophilic-lipophilic balance (HLB) value of lipophilic fractions of emulsions. The emulsions were prepared by the spontaneous emulsification process with HLB value from 4.3 to 16.7. The preparations were stored at 2 different temperatures (25°C and 4°C) and their physicochemical behavior was evaluated by the micro-emultocrit technique and the long-term stability study. The experimental data show a reverse relationship between HLB values of the surfactant mixtures and emulsion stability. A close correlation between the results for both stability procedures was observed, suggesting the use of micro-emultocrit to predict stabilities of such systems. In addition, it was found that the critical HLB of the Mygliol 812 was 15.367.
