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Updated: Mar 6, 2026

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
Published on: September 7, 2022
The "Choosing Wisely" initiative in infectious diseases
Clara Lehmann1,2, Reinhard Berner3, Johannes R Bogner4
1Department I of Internal Medicine, University of Cologne, Cologne, Germany. clara.lehmann@uni-koeln.de.
The German Society of Infectious Diseases developed ten "Choosing Wisely" recommendations to optimize patient care by guiding essential diagnostic and treatment choices. Implementing these guidelines reduces unnecessary procedures and improves healthcare value.
Area of Science:
- Infectious Diseases
- Internal Medicine
- Public Health
Background:
- The international "Choosing Wisely" campaign promotes evidence-based medical practices.
- It aims to reduce unnecessary procedures and improve patient safety.
- The German Society of Infectious Diseases (DGI) participates to address overuse and underuse in infectious disease management.
Purpose of the Study:
- To develop a list of
Main Methods:
- Committee members of the DGI identified potential "Choosing Wisely" items.
- Topics underwent systematic evidence review.
- The top ten items were selected, with five positive and five negative recommendations approved by member vote.
Main Results:
- Recommendations cover Staphylococcus aureus bloodstream infections, antibiotic use in critically ill patients, influenza and measles vaccination.
- Guidelines address oral antimicrobial preference, avoiding antibiotics for uncomplicated upper respiratory infections and asymptomatic bacteriuria.
- Specific recommendations include not treating Candida in respiratory/GI specimens, limiting prophylactic antibiotic duration, and avoiding antibiotics for elevated CRP/procalcitonin without infection signs.
Conclusions:
- Implementing these "Choosing Wisely" recommendations can reduce patient harm.
- These guidelines enhance the value of healthcare delivery in infectious diseases.
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