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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
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[Hemodynamic Derangements in Patients With Functional Univentricular Heart: Mechanisms of Development, Possibilities

I A Kovalev1,2,3, S Ovroutski1,2,3, I V Plotnikova1,2,3

  • 1Research Institute of Clinical Pediatrics named after Acad. Yu.E. Veltischev Pirogov Russian National Research Medical University,Moscow, Russia.

Kardiologiia
|March 15, 2017
PubMed

Insights

Heart failure (HF) in functional single ventricle (FSV) patients arises from complex factors. Management involves surgical, medical, and advanced therapies for improved outcomes.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Congenital Heart Disease

Background:

  • Heart failure (HF) is a common complication in cardiovascular diseases, particularly congenital heart diseases (CHD).
  • Patients with functional single ventricle (FSV) present unique challenges due to anatomical diversity and complex HF development.
  • Multistage surgical correction, arrhythmias, and pulmonary vascular resistance significantly impact HF in FSV patients.

Discussion:

  • HF in FSV stems from intricate anatomical and physiological factors.
  • Treatment strategies are multifaceted, including neonatal surgical optimization, staged correction, pharmacotherapy, and cardiac resynchronization.
  • Advanced interventions like mechanical support and heart transplantation are options for severe cases.

Key Insights:

  • FSV patients represent a distinct group with complex HF mechanisms.
  • Comprehensive management strategies are crucial for addressing HF in this population.
  • Early intervention and tailored treatment plans are essential.

Outlook:

  • Further research into novel therapeutic targets for FSV-related HF is warranted.
  • Optimizing long-term management strategies for FSV patients is critical.
  • Advancements in surgical techniques and medical therapies may improve HF prognosis.

Keywords:
congenital heart diseasefunctional single ventricleheart failure

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