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[Dynamics of Biochemical Markers of Endothelial Dysfunction in Patients With Arterial Hypertension]

V I Podzolkov1, A I Tarzimanova1

  • 1Sechenov First Moscow State Medical University, Moscow, Russia.

Kardiologiia
|March 15, 2017
PubMed

Insights

Arterial hypertension (AH) and atrial fibrillation (AF) increase cardiovascular risk. This study links endothelial dysfunction markers, like von Willebrand factor, to AF in hypertensive patients, aiding risk prediction.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Arterial hypertension (AH) is a primary cause of atrial fibrillation (AF).
  • AF in hypertensive patients significantly heightens cardiovascular complication risks.
  • Endothelial dysfunction (ED) may predict thromboembolic complications in AH patients with AF.

Purpose of the Study:

  • To investigate biochemical markers of ED in patients with AH and different forms of AF.
  • To assess the prognostic value of ED markers for thromboembolic risk stratification.

Main Methods:

  • Studied collagen binding activity of von Willebrand factor (vWF).
  • Measured plasma endothelin concentrations.
  • Correlated ED markers with AH severity and AF characteristics (paroxysmal frequency).

Main Results:

  • Collagen binding activity of vWF was significantly higher in permanent AF patients versus controls, independent of AH severity.
  • A moderate correlation was found between annual AF paroxysm frequency and vWF activity in persistent AF.
  • Endothelin levels increased with AH severity in both AF and non-AF patients, irrespective of AF form.

Conclusions:

  • Elevated vWF activity is associated with permanent AF in hypertensive individuals.
  • vWF activity may correlate with AF burden in persistent AF.
  • Endothelin levels reflect AH severity but not AF type.

Keywords:
arterial hypertensionatrial fibrillationendothelinvon Willebrand factor

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