Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Anesthesia: Overview01:24

General Anesthesia: Overview

911
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
911
Stages of General Anesthesia01:22

Stages of General Anesthesia

2.0K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
2.0K
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

844
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
844
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

976
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
976
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

1.3K
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
1.3K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

294
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
294

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Building resilience in perioperative medicine: ensuring safe care for all: A white paper from the European society of anaesthesiology and intensive care (ESAIC).

European journal of anaesthesiology·2026
Same author

Risk of postoperative respiratory complications in adults treated with GLP-1 receptor agonists: a propensity-matched population-based study.

British journal of anaesthesia·2026
Same author

The Østergaard Declaration: A European Society of Anaesthesiology and Intensive Care statement on advancing simulation-based education and training.

European journal of anaesthesiology·2026
Same author

Perioperative anemia and patient blood management in neurosurgery and neurocritical care: a narrative review.

Journal of anesthesia, analgesia and critical care·2026
Same author

Stillbirth labour pain still matters: an anaesthesiology call to action for parent-centred care.

European journal of anaesthesiology·2026
Same author

Thoracoscopic lobectomy for early-stage non-small cell lung carcinoma: initial experience from a newly established Israeli center.

Journal of thoracic disease·2026
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
Same journal

Airway ultrasound in patients undergoing head and neck surgery.

Current opinion in anaesthesiology·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

741

Frailty and anesthesia.

Lior Shem Tov1, Idit Matot

  • 1Division of Anesthesiology, Pain and Intensive Care, Sackler Medical School, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.

Current Opinion in Anaesthesiology
|March 15, 2017
PubMed
Summary
This summary is machine-generated.

Frailty syndrome significantly increases perioperative morbidity and mortality. Preoperative frailty assessment tools can predict adverse events, guiding interventions for frail elderly patients.

More Related Videos

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K
Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.4K

Related Experiment Videos

Last Updated: Mar 6, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

741
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K
Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.4K

Area of Science:

  • Geriatric Medicine
  • Perioperative Care
  • Surgical Outcomes

Background:

  • Frailty syndrome is characterized by reduced physiological reserve, impairing the ability to respond to stress.
  • This diminished reserve is particularly relevant in the perioperative period, increasing patient vulnerability.

Purpose of the Study:

  • To review current understanding of frailty syndrome.
  • To explore its association with the perioperative period, including organ system relevance, assessment tools, and interventions.

Main Methods:

  • Literature review of contemporary concepts and research on frailty syndrome.
  • Discussion of various frailty assessment tools and their predictive capabilities.

Main Results:

  • Frail patients exhibit a reduced capacity to cope with perioperative physical stress.
  • Preoperative frailty assessment tools show promise in predicting perioperative morbidity and mortality.
  • Preoperative optimization strategies for frail patients have yielded mixed results.

Conclusions:

  • Preoperative frailty is a significant predictor of adverse outcomes, including morbidity and mortality.
  • Emerging frailty assessment tools can aid in patient selection and guide perioperative interventions.
  • Routine use of these tools may improve outcomes for the frail elderly population.