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Related Experiment Video

Updated: Mar 6, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Cartilage suspension using a poly (lactic-co-glycolic) acid system.

Jae Hoon Jeong¹, Byung Hwi Kim¹, Dae Hee Kim¹

¹Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS

|March 15, 2017

Summary

Poly lactic-co-glycolic acid (PLGA) bar-like implants effectively support cartilage in rhinoplasty. Animal studies show PLGA implants maintain cartilage shape and are safe for nasal septal suspension.

Keywords:

Biomaterials Cartilage Polylactic acid/polyglycolic acid copolymer Rabbits Rhinoplasty

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Area of Science:

Biomaterials Science
Regenerative Medicine
Plastic Surgery

Background:

Investigating novel biomaterials for cartilage reconstruction.
Assessing the potential of poly lactic-co-glycolic acid (PLGA) implants in plastic surgery.

Purpose of the Study:

To evaluate a bar-like PLGA implant for cartilage suspension.
To determine the suitability of PLGA implants for rhinoplasty applications.

Main Methods:

In vivo animal models using rabbit ear cartilage for suspension and retention tests.
Histological and micro-computed tomography (CT) evaluations at 12 weeks post-implantation.
Nasal septal suspension using PLGA bar-like implants in rabbits.

Main Results:

PLGA implants successfully maintained cartilage shape in ear suspension and bending tests.
No abnormal inflammatory responses were observed in any experimental sites.
Successful nasal septal suspension with PLGA implants, showing no obstruction or inflammation.

Conclusions:

PLGA implants demonstrate stability and biocompatibility within cartilage tissue.
PLGA implants offer a promising alternative to autologous cartilage in rhinoplasty.
The study supports the clinical application of PLGA implants for nasal reconstruction.