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Updated: Jul 2, 2026
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Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry
Published on: December 9, 2025
Quantitative Assessment of Polydioxanone Microsphere Fillers for Nasolabial Fold Correction: A Comparative Study
Nguyen Ngan Giang1,2, Linh Thi Thuy LE2,3,4, Caijun Jin2,5
1Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea.
In Vivo (Athens, Greece)
|June 30, 2026
Summary
Polydioxanone (PDO) fillers significantly improve facial volume and skin texture compared to hyaluronic acid and other alternatives. This study confirms PDO fillers as an effective option for non-surgical facial rejuvenation.
Area of Science:
- Aesthetic medicine
- Dermatology
- Biomaterials science
Background:
- Dermal fillers are crucial for facial rejuvenation.
- Polydioxanone (PDO) fillers offer a novel approach to wrinkle improvement.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of a PDO-based filler.
- To compare its performance against established commercial fillers for nasolabial fold wrinkles.
Main Methods:
- A prospective, split-face study involving 31 participants (aged 20-59).
- Quantitative 3D imaging (ANTERA 3D CS) assessed skin texture and volume at baseline and post-injection.
- Comparison of PDO filler against hyaluronic acid, poly(D,L-lactic acid), and polynucleotide fillers.
Main Results:
- PDO filler demonstrated superior volume restoration and skin texture refinement compared to all control fillers (p<0.05).
- At week 8, PDO achieved 22.68% volume reduction versus 7.69% for HA, and 12.07% skin texture improvement (2.22x PDLLA).
Conclusions:
- PDO filler shows significant clinical efficacy in improving skin texture and volume.
- Objective data supports PDO fillers as a viable non-surgical option for facial rejuvenation.