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Related Experiment Video

Updated: Mar 6, 2026

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

Pixel response-based EPID dosimetry for patient specific QA.

Bin Han¹, Aiping Ding¹, Minghui Lu²

¹Radiation Oncology Department, Stanford University, Stanford, CA, USA.

Journal of Applied Clinical Medical Physics

|March 15, 2017

Summary

This summary is machine-generated.

This study presents a novel method using an electronic portal imaging device (EPID) for accurate radiation dose measurements. The validated technique enhances quality assurance for advanced radiation therapy techniques.

Keywords:

EPID Monte Carlo dosimetry patient‐specific QA

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

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Last Updated: Mar 6, 2026

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

Medical Physics
Radiation Oncology
Medical Imaging

Background:

Modern radiation therapy increasingly uses high dose rate, flattening filter-free (FFF), and small field beams.
These beams pose significant dosimetric challenges for the medical physics community.
Accurate dose verification is crucial for patient safety and treatment efficacy.

Purpose of the Study:

To develop and validate a dosimetry strategy using a high spatial resolution, high frame rate amorphous silicon flat panel electronic portal imaging device (EPID).
To enable accurate dosimetric measurements for challenging beams (FFF, small fields) and conventional external beam therapy.
To provide an independent verification tool for modern radiation therapy quality assurance (QA).

Main Methods:

Developed a pixel-to-pixel dose-response function for the EPID using Monte Carlo simulations and comprehensive calibration.
Converted raw EPID images to primary incident photon fluence, then convolved to water-based dose distributions using a pre-generated pencil-beam kernel.
Validated the EPID-based dosimetry technique against ion chamber array measurements in plastic water phantom for various field types and sizes on a Varian TrueBeam STx™.

Main Results:

EPID measurements of absolute 2D dose maps agreed with ion chamber measurements within 1.5% for all tested field configurations.
For 23 patient treatment plans, average gamma-index passing rates were 99.2% (3 mm/3%), 97.4% (2 mm/2%), and 72.6% (1 mm/1%).
The high spatial resolution and frame rate of the EPID enable accurate and efficient dosimetric measurements.

Conclusions:

The developed EPID-based dosimetry technique provides an accurate and efficient tool for quality assurance in modern radiation therapy.
The system can generate accurate absolute 2D dose maps for independent verification of treatment delivery.
This method addresses the challenges posed by advanced beam configurations in radiation oncology.