Related Experiment Video

Updated: Mar 6, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

4.5K

[High Serum Concentrations of Uric Acid: Clinical and Prognostic Significance in Chronic Heart Failure]

V N Larina1, B Y Bart1, V G Larin1

  • 11N.I. Pirogov Russian National Research State Medical University, Moscow, Russia; 2 Clinical sanatorium Barvikha of the Business Administration of the President of the Russian Federation, Moscow region, Barvikha, Russia; 3Medical Department of the Business Administration of the President of the Russian Federation, Moscow, Russia.

Kardiologiia
|March 16, 2017
PubMed

Insights

Asymptomatic hyperuricemia, or elevated uric acid, is linked to higher risks of chronic heart failure (CHF) and worse outcomes in patients. This review explores uric acid metabolism and management strategies for heart failure patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Diseases

Background:

  • Elevated serum uric acid levels are increasingly recognized as a significant risk factor in cardiovascular disease.
  • Hyperuricemia is associated with increased incidence and adverse outcomes in patients diagnosed with chronic heart failure (CHF).

Purpose of the Study:

  • To review the clinical significance of asymptomatic hyperuricemia in patients with chronic heart failure (CHF).
  • To summarize epidemiological evidence linking elevated uric acid to CHF risk and outcomes.
  • To discuss therapeutic strategies for managing uric acid metabolism disturbances in CHF.

Main Methods:

  • Systematic review of epidemiological studies and clinical reports.
  • Analysis of data correlating serum uric acid levels with CHF incidence and prognosis.
  • Literature synthesis on pharmacological and non-pharmacological interventions for hyperuricemia.

Main Results:

  • Multiple epidemiological studies demonstrate a strong association between higher serum uric acid and increased risk of developing CHF.
  • In patients with established CHF, elevated uric acid levels predict poorer clinical outcomes and higher mortality rates.
  • Disturbances in uric acid metabolism are prevalent in CHF populations.

Conclusions:

  • Asymptomatic hyperuricemia is a valuable prognostic marker in chronic heart failure (CHF) patients.
  • Management of uric acid metabolism may offer a novel therapeutic target for improving outcomes in CHF.
  • Further research is warranted to establish optimal treatment guidelines for hyperuricemia in CHF.

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.3K
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

704

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
835
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
545
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
743
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
534
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.1K
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
547