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Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in

Amy C Justice1,2,3, Kathleen A McGinnis2, Janet P Tate1

  • 1Yale School of Medicine, New Haven, Connecticut.

Alcoholism, Clinical and Experimental Research
|March 16, 2017
PubMed
Summary

Longitudinal trajectories of alcohol use, measured by AUDIT-C in electronic health records, offer a valid phenotype for genetic studies. This approach enhances the identification of genetic variants associated with harmful alcohol consumption.

Keywords:
ADH1BAUDIT-CAfrican AmericanAlcohol Use DisorderArg369CysElectronic Health Record DataTrajectory Analysesrs2066702

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