Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.7K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.9K
Plant Hormones01:56

Plant Hormones

27.7K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.7K
Types of Hormones02:13

Types of Hormones

83.8K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.8K
Types of Hormones01:21

Types of Hormones

7.2K
Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
7.2K
Hormonal Regulation01:33

Hormonal Regulation

36.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shift from a Zero-COVID strategy to a New-normal strategy for controlling SARS-COV-2 infections in Vietnam - CORRIGENDUM.

Epidemiology and infection·2026
Same author

Impact of Removing Restrictive Haemoglobin A1C Eligibility Criteria for Insulin Pump Therapy Funding for Children With Type 1 Diabetes in Ontario, Canada.

Diabetes, obesity & metabolism·2026
Same author

Sarcopenia Severity and the Accumulation of Geriatric Syndromes Among Older Adults: A Cross-Sectional Study from Vietnam.

Geriatrics (Basel, Switzerland)·2026
Same author

A Patient-Clinician Co-Designed Infographic for Diabetic Ketoacidosis Education in Type 1 Diabetes.

Canadian journal of diabetes·2026
Same author

Health related quality of life among hypertensive adults living in rural Vietnam: Results from a cluster-randomised controlled trial.

PloS one·2026
Same author

Barriers and Enablers to Diabetes Technologies Use Among Individuals With Type 1 Diabetes: A Scoping Review.

Diabetes, obesity & metabolism·2026
Same journal

Evaluating Restraint and Seclusion as Care Processes Rather Than Compliance Metrics.

Journal of evaluation in clinical practice·2026
Same journal

Burden in Informal Caregivers of Palliative Care Patients With Pressure Injuries: Perceived Social Support and Influencing Factors Care Burden in Palliative Caregivers.

Journal of evaluation in clinical practice·2026
Same journal

Organisational Problems, Role Stress, and Job Satisfaction Among Emergency Department Workers: A Multicenter Mixed-Effects Study.

Journal of evaluation in clinical practice·2026
Same journal

Highlighting a Systemic Bias in the Responder Odds Ratio.

Journal of evaluation in clinical practice·2026
Same journal

Epistemological Issues in Clinical Reasoning: A Scoping Review.

Journal of evaluation in clinical practice·2026
Same journal

An Evaluation of AI-Generated Clinical Notes in the OpenNotes Era: A Thematic Analysis of Clinician Discourse.

Journal of evaluation in clinical practice·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production
09:36

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Published on: November 17, 2023

14.6K

Promoting resource stewardship: Reducing inappropriate free thyroid hormone testing.

Julie A Gilmour1,2, Alanna Weisman1, Steven Orlov1,3

  • 1Department of Medicine, Division of Endocrinology & Metabolism, University of Toronto, Toronto, Ontario, Canada.

Journal of Evaluation in Clinical Practice
|March 16, 2017
PubMed
Summary
This summary is machine-generated.

Reducing inappropriate free thyroxine (fT4) and free triiodothyronine (fT3) testing is crucial for resource stewardship. A reflex fT4 strategy significantly decreased fT4 and fT3 tests by 49%.

Keywords:
PDSAforced functionquality improvementresource stewardshipthyroid

More Related Videos

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

778
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.3K

Related Experiment Videos

Last Updated: Feb 9, 2026

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production
09:36

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Published on: November 17, 2023

14.6K
Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

778
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.3K

Area of Science:

  • Endocrinology
  • Laboratory Medicine
  • Healthcare Management

Background:

  • Free thyroxine (fT4) and free triiodothyronine (fT3) testing is frequently overused in clinical practice.
  • Unnecessary laboratory testing strains healthcare resources and impacts stewardship efforts.

Purpose of the Study:

  • To quantify the incidence of inappropriate fT4 and fT3 testing.
  • To implement and assess a quality improvement initiative to reduce these tests.

Main Methods:

  • Employed quality improvement tools, including physician education on appropriate test indications.
  • Implemented a hospital-wide laboratory system with a forced-function and reflex fT4 testing protocol.
  • Utilized statistical process control charts to analyze weekly test volumes (TSH, fT4, fT3) across preintervention, education, and reflex periods.

Main Results:

  • Weekly fT4/fT3 test volumes decreased significantly from baseline (90/39) to post-education (78/34) and post-reflex (59/14).
  • The reflex strategy resulted in a 34% reduction in fT4 and a 64% reduction in fT3 testing.
  • Thyroid-stimulating hormone (TSH) test volumes remained stable, with only a 2% variation.

Conclusions:

  • Inappropriate free thyroid index testing is a common issue.
  • A reflex fT4 strategy, combined with physician education, is a feasible and effective method for reducing unnecessary thyroid function tests.
  • This approach successfully promotes laboratory resource stewardship.