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Related Concept Videos

Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

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Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
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DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
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Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
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Bioengineered hemodialysis access grafts.

Shawn M Gage1,2, Jeffrey H Lawson3,4

  • 1Clinical Operations, Humacyte, Inc., Morrisville, NC - USA.

The Journal of Vascular Access
|March 16, 2017
PubMed
Summary
This summary is machine-generated.

Bioengineered grafts offer durable vascular access for hemodialysis patients. Ongoing research in tissue engineering aims to improve graft efficiency, variety, and reduce costs for better patient outcomes.

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Vascular Surgery

Background:

  • Patients with renal failure require lifelong hemodialysis vascular access.
  • Current access methods present challenges in durability and patient outcomes.
  • Bioengineered therapies are crucial for improving global health, especially for aging populations.

Purpose of the Study:

  • To review the historical development of tissue engineering for hemodialysis vascular access grafts.
  • To explore various strategies employed in creating bioengineered vessels.
  • To discuss the future prospects and potential improvements in this field.

Main Methods:

  • Review of historical and current tissue engineering strategies for vascular grafts.
  • Analysis of approaches including vessel fixation, cell seeding, and de novo vessel synthesis.
  • Examination of clinical trial progress and emerging technologies.

Main Results:

  • Multiple tissue engineering strategies have been developed for hemodialysis vascular access.
  • Two distinct tissue engineering technologies have advanced to Phase 2 and Phase 3 clinical trials.
  • Emerging strategies promise enhanced manufacturing, diverse graft options, and reduced production costs.

Conclusions:

  • Tissue engineering has made significant strides in developing bioengineered grafts for hemodialysis.
  • Clinical translation is underway, with ongoing innovation expected to further optimize graft performance and accessibility.
  • Future advancements hold the potential to revolutionize vascular access for renal failure patients.