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Related Experiment Video

Updated: Mar 6, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

HLA-A*24:374-A novel allele encoding the HLA-A2403 specificity.

J Rowlands¹, T Climer¹, C Harvey¹

¹Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Pontyclun, Wales, UK.

|March 16, 2017

Summary

This summary is machine-generated.

A novel Human Leukocyte Antigen (HLA) allele, HLA-A*24:374, has been identified. It differs from HLA-A*24:03:01:01 by two bases, leading to a T163E amino acid substitution.

Keywords:

HLA-A*24:374 HLA-A24 HLA-A2403

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Last Updated: Mar 6, 2026

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Area of Science:

Immunogenetics
Molecular Biology

Background:

Human Leukocyte Antigen (HLA) genes are crucial for immune response.
Polymorphisms in HLA alleles contribute to diverse immune capabilities.

Purpose of the Study:

To report the discovery and characterization of a new HLA-A allele.

Main Methods:

Sequence analysis of HLA gene.
Comparison with known HLA allele sequences.

Main Results:

A novel allele, HLA-A*24:374, was identified.
This allele differs from HLA-A*24:03:01:01 by two nucleotide bases in exon 3.
The identified base changes result in a single amino acid substitution (Threonine to Glutamic acid at position 163).

Conclusions:

The characterization of HLA-A*24:374 expands the known HLA-A allele repertoire.
This finding contributes to the understanding of HLA polymorphism and its implications in immunogenetics.