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Predictors for spontaneous pregnancy after microsurgical subinguinal varicocelectomy: a prospective cohort study
Jian-Wei Zhang1, Quan-Quan Xu2, You-Lin Kuang2
1Department of Urology Surgery, The First Affiliated Hospital of Zhengzhou University, # 1 Jian She Dong Road, Zhengzhou, 450052, Henan, China. zhangjianwei112567@163.com.
International Urology and Nephrology
|March 17, 2017
Summary
Microsurgical varicocelectomy improves pregnancy chances for infertile men. Higher total motile sperm count and lower follicle-stimulating hormone levels preoperatively predict successful spontaneous pregnancy after surgery.
Area of Science:
- Reproductive Medicine
- Andrology
- Surgical Urology
Background:
- Varicocele is a common cause of male infertility.
- Microsurgical subinguinal varicocelectomy (MVL) is a standard treatment for varicocele.
- Predictors of spontaneous pregnancy after MVL require further investigation.
Purpose of the Study:
- To identify preoperative predictors of spontaneous pregnancy (SPR) in infertile males with varicocele.
- To analyze factors influencing successful conception post-microsurgical varicocelectomy (MVL).
Main Methods:
- Prospective cohort study of 120 males with varicocele undergoing MVL.
- Data collected: patient demographics, semen parameters, hormone levels, varicocele characteristics.
- Follow-up for 2 years to assess SPR using Cox regression analysis.
Main Results:
- Of 110 patients completing follow-up, 42 achieved SPR.
- Total motile sperm count (TMC) was a significant positive predictor (RR=1.362, p=0.003).
- Follicle-stimulating hormone (FSH) level was a significant negative predictor (RR=0.726, p=0.020).
Conclusions:
- Preoperative higher TMC and lower FSH levels are associated with increased SPR after MVL.
- These parameters can help counsel infertile men undergoing varicocelectomy.
