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Related Concept Videos

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Related Experiment Video

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Human Blastocyst Biopsy and Vitrification
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Human Blastocyst Biopsy and Vitrification

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Elective single blastocyst transfer in advanced maternal age.

Samer Tannus1, Weon-Young Son2, Michael Haim Dahan2

  • 1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill University Health Center, Royal Victoria hospital, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada. sr.tannus@gmail.com.

Journal of Assisted Reproduction and Genetics
|March 17, 2017
PubMed
Summary
This summary is machine-generated.

Elective single blastocyst transfer (eSBT) shows similar live birth rates (LBRs) to double blastocyst transfer (DBT) in women aged 40+. However, elective DBT offers higher LBRs when extra embryos are available for freezing.

Keywords:
Advanced maternal ageElective single blastocyst transferLive birth rateMultiple birth rate

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)

Background:

  • Advanced maternal age (40+) presents unique challenges in achieving successful pregnancy through IVF.
  • Blastocyst transfer has become a standard practice, but the optimal number of embryos to transfer remains a topic of research.

Purpose of the Study:

  • To compare reproductive outcomes between elective single blastocyst transfer (eSBT) and double blastocyst transfer (DBT) in women aged 40 and over.
  • To evaluate live birth rates (LBRs) and multiple birth rates in different blastocyst transfer strategies.

Main Methods:

  • Retrospective cohort study at an academic fertility center.
  • Inclusion of women aged 40+ undergoing IVF with blastocyst culture, excluding specific cases like donor oocytes or genetic screening.
  • Analysis of 310 women (148 eSBT, 162 DBT) using logistic regression, controlling for embryo quality and prior IVF cycles.

Main Results:

  • Similar clinical pregnancy rates (33% vs. 33%) and LBRs (20% vs. 22.8%) between eSBT and DBT groups.
  • Significantly lower multiple birth rate in the eSBT group (0% vs. 16%).
  • Elective DBT (eDBT) subgroup showed higher LBR (30.6%) and multiple birth rate (22%) compared to eSBT.

Conclusions:

  • eSBT is a viable option with comparable LBRs to the overall DBT cohort in advanced maternal age.
  • When cryopreservation is utilized, eDBT can lead to higher cumulative LBRs but also increases the risk of multiple births.
  • Further research is needed on cumulative LBRs following single blastocyst transfer and subsequent frozen-thawed embryo transfers in this age group.