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Circumpapillary ganglion cell complex thickness to diagnose glaucoma: A pilot study
Yoshiyuki Kita1, Norihisa Soutome2, Daisuke Horie1
1Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan.
Indian Journal of Ophthalmology
|March 17, 2017
Summary
The circumpapillary ganglion cell complex (cpGCC) thickness shows lower diagnostic accuracy than macular GCC (mGCC) for glaucoma in Japanese eyes. However, cpGCC may aid diagnosis when macular disease hinders mGCC measurements.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Diagnostics
Background:
- Glaucoma diagnosis relies on detecting retinal nerve damage.
- Optical coherence tomography (OCT) parameters like macular ganglion cell complex (mGCC) and circumpapillary retinal nerve fiber layer (cpRNFL) are used.
- New OCT parameters require evaluation for improved diagnostic capabilities.
Purpose of the Study:
- To assess the diagnostic applicability of a novel OCT parameter, circumpapillary ganglion cell complex (cpGCC) thickness, for glaucoma.
- To compare the diagnostic performance of cpGCC with established OCT parameters.
Main Methods:
- The RS-3000 Advance SD-OCT was used to measure mGCC, cpRNFL, cpGCC, and circumpapillary total retina (cpTR) thickness.
- Measurements were taken in Japanese participants, including healthy individuals and those with preperimetric/early primary open-angle glaucoma.
- Area under the receiver-operating characteristic (AUROC) curves were calculated for performance comparison.
Main Results:
- Global mGCC demonstrated the highest diagnostic accuracy (AUROC 0.917), significantly outperforming cpRNFL, cpGCC, and cpTR.
- cpGCC showed significantly higher AUROC than cpRNFL in global and temporal sectors.
- cpGCC, cpTR, and cpRNFL detected additional glaucoma cases missed by mGCC at >90% specificity.
Conclusions:
- In the Japanese population, cpGCC thickness has lower diagnostic accuracy for glaucoma compared to mGCC but is superior to cpRNFL.
- cpGCC may not enhance glaucoma diagnostics in the absence of macular pathology.
- cpGCC could be beneficial in cases where macular diseases impede accurate mGCC measurements.
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