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Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
Lovro Žiberna1, Dunja Šamec2, Andrei Mocan3,4
1Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia. lovro.ziberna@mf.uni-lj.si.
International Journal of Molecular Sciences
|March 17, 2017
Summary
Oleanolic acid, a phytochemical from olive oil, shows potential in preventing and treating cancer by targeting key signaling pathways. This review explores its molecular mechanisms, sources, and safety for therapeutic use.
Area of Science:
- Phytochemistry
- Molecular Biology
- Oncology
Background:
- Dietary supplements are explored for chronic disease management.
- Cancer involves complex intracellular signaling pathway deregulation.
- Phytochemicals demonstrate promising anticancer properties.
Purpose of the Study:
- To review the scientific literature on oleanolic acid's molecular targets in cancer.
- To discuss the chemical aspects, sources, bioavailability, and safety of oleanolic acid.
Main Methods:
- Literature review of preclinical and epidemiological evidence.
- Analysis of molecular mechanisms of oleanolic acid's anticancer effects.
- Discussion of chemical properties and natural sources.
Main Results:
- Oleanolic acid inhibits inflammation and induces xenobiotic enzymes.
- Its anticancer effects are mediated by various signaling pathways (e.g., caspases, AMPK, ERK1/2, NF-κB).
- Evidence suggests oleanolic acid's role in preventing and treating multiple cancer types.
Conclusions:
- Oleanolic acid is a promising phytochemical for cancer prevention and treatment.
- Further research into its molecular targets and therapeutic applications is warranted.
- Understanding its bioavailability and safety is crucial for clinical use.
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