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Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain
S R Bodnoff1, B Suranyi-Cadotte, R Quirion
1Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Canada.
European Journal of Pharmacology
|November 24, 1987
Abstract:
Postnatal handling of rat pups alters their response to novelty. We have now shown that, as adults, rats handled for the first three weeks of life showed a suppression of feeding in a novel environment that was less, and a [3H]flunitrazepam binding in whole brain that was greater than in non-handled animals. These data suggest that variations in benzodiazepam binding capacity could be related to individual differences in the fear response to novelty.