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Related Concept Videos

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

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Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
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Diffusion01:12

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion01:21

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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

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Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
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Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
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Maxwell-Boltzmann Distribution: Problem Solving01:20

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Individual molecules in a gas move in random directions, but a gas containing numerous molecules has a predictable distribution of molecular speeds, which is known as the Maxwell-Boltzmann distribution, f(v).
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Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
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Applying diffusion-based Markov chain Monte Carlo.

Radu Herbei1, Rajib Paul2, L Mark Berliner1

  • 1The Ohio State University, Department of Statistics, Columbus, OH, United States of America.

Plos One
|March 17, 2017
PubMed
Summary
This summary is machine-generated.

Diffusion Markov chain Monte Carlo (MCMC) offers a simpler, faster alternative to traditional algorithms for Bayesian analysis. This novel approach, based on stochastic differential equations, requires less tuning and handles complex models effectively.

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Area of Science:

  • Computational Statistics
  • Bayesian Inference
  • Numerical Methods

Background:

  • Markov chain Monte Carlo (MCMC) methods are essential for Bayesian analysis.
  • Traditional MCMC algorithms can be complex to implement and tune, especially for nonlinear models.
  • Stochastic differential equations (SDEs) offer a continuous-time framework that can be approximated discretely.

Purpose of the Study:

  • To introduce and evaluate Diffusion MCMC, a novel MCMC strategy.
  • To demonstrate the simplicity and efficiency of Diffusion MCMC in Bayesian analyses.
  • To compare Diffusion MCMC performance against established algorithms like Metropolis-Hastings.

Main Methods:

  • Simulating a discrete approximation to a stochastic differential equation (SDE).
  • Implementing the Diffusion MCMC algorithm.
  • Assessing performance using a test case and a glaciological application.

Main Results:

  • Diffusion MCMC is straightforward to implement, even with nonlinear models and non-conjugate priors.
  • The method requires minimal problem-specific tuning.
  • In certain scenarios, Diffusion MCMC demonstrates superior speed compared to general Metropolis-Hastings algorithms.

Conclusions:

  • Diffusion MCMC presents a computationally efficient and user-friendly alternative for Bayesian inference.
  • Its performance advantages make it a valuable tool for complex statistical modeling.
  • The approach shows promise for applications in various scientific domains, including glaciology.