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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Periodontitis and Systemic Disease: Association or Causality?
Lewis Winning1, Gerard J Linden1,2
1Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Current Oral Health Reports
|March 18, 2017
Summary
Recent evidence suggests diabetes, metabolic syndrome (MetS), and obesity may worsen periodontitis progression. However, confounding factors complicate causal links, particularly for obesity, warranting further research.
Area of Science:
- Periodontology
- Metabolic Health
- Epidemiology
Background:
- Diabetes, metabolic syndrome (MetS), and obesity are prevalent conditions.
- Periodontitis is a common inflammatory disease affecting tooth-supporting structures.
Purpose of the Study:
- To review recent evidence on the impact of diabetes, MetS, and obesity on periodontitis progression.
- To synthesize findings from epidemiological studies published between 2014 and 2016.
Main Methods:
- Conducted electronic searches in Embase, Medline, and Web of Science.
- Included human epidemiological studies and systematic reviews.
- Focused on literature published from 2014 to 2016.
Main Results:
- Identified a limited number of prospective studies and systematic reviews.
- Findings generally support an adverse association between diabetes, MetS, obesity, and periodontal status.
- Recent Mendelian randomization studies question the causal role of obesity in periodontitis.
Conclusions:
- Confounding remains a significant challenge in interpreting the relationship between these conditions.
- The causal link between obesity and periodontitis is debated and requires further investigation.
- Additional research is necessary to establish causality.
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