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Protein kinase activity, growth and differentiation of murine erythroleukemia cells
1Department of Biological Sciences, State University of New York, Buffalo 14260.
Cancer Letters
|February 1, 1988
Abstract:
The addition of type 2 cAMP-dependent protein kinase stimulates division of cultured Friend erythroleukemia cells. A synthetic peptide representing the inhibitory portion of the heat stable protein kinase inhibitor protein and an inhibitor of cAMP-dependent protein kinase (N-(2-aminoethyl)-5-isoquinolinesulfonamide dihydrochloride or H-9) inhibited cell division. The latter inhibitor (H-9) induced differentiation of the cells.