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Expert Views on Biological Threat Characterization for the U.S. Government: A Delphi Study.

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Area of Science:

  • Biosecurity and biodefense research.
  • Biological threat characterization (BTC).

Background:

  • BTC research is crucial for enhancing biological risk assessment and prioritizing resources for national defense.
  • However, BTC activities pose inherent risks, including accidental release and potential misuse of findings.

Purpose of the Study:

  • To explore principles and safeguards for maximizing benefits and ensuring safety and security in BTC research.
  • To gather expert opinions on the necessity, risks, and oversight of US government-funded BTC.

Main Methods:

  • A modified Delphi study involving U.S. experts in biosecurity and biodefense.
  • Experts provided opinions on BTC research needs, risks, guidelines, review processes, and prioritization responsibilities.

Main Results:

  • Findings underscore the necessity of federal-level BTC research.
  • Continued review and oversight are essential to maximize effectiveness and mitigate risks.
  • Further discussion is needed on research "red lines" and criteria for discontinuing characterization studies.

Conclusions:

  • Federal BTC research requires ongoing oversight to balance benefits and risks.
  • Establishing clear ethical and safety boundaries is critical for responsible research conduct.
  • Defining completion criteria for pathogen characterization studies is necessary.