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Updated: Jan 9, 2026

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

Increasing Gene Synthesis Security Risk Awareness Through Global Engagement and Collaborative Exercise Development.

Amanda Kobokovich Mui¹, Gigi Kwik Gronvall¹, Oliver Shane R Dumaoal¹

¹Amanda Kobokovich Mui, MPH, is Managing Senior Analyst, Johns Hopkins Center for Health Security, and Senior Research Associate, Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Gigi Kwik Gronvall, PhD, is Professor, Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Oliver Shane R. Dumaoal, RMT, MSMT, is Director of the School of Health Sciences, UST General Santos, General Santos City; Academic Staff, University of Santo Tomas, España, Manila; and Vice President, BioRisk Association of the Philippines, Quezon City; all in the Philippines. Viswanadham Duppatla, PhD, is Vice President, IKP Knowledge Park, Genome Valley, Hyderabad, India. Benard W. Kulohoma, PhD, is Director of Organization Capacity Development, IAVI, Nairobi, Kenya. Damaris Matoke-Muhia, PhD, is a Senior Principal Research Scientist, Centre for Biotechnology Research and Development, Kenya Medical Research Institute, Nairobi, Kenya. Margaret W. Muturi, PhD, is an Associate Professor, Department of Medical Laboratory Science, Kenyatta University, Nairobi, Kenya. Shambhavi Naik, PhD, is Head of Research and Chairperson, Advanced Biology Programme, Takshashila Institution, Bengaluru, India. George Ogello Obiero, PhD, is an Associate Professor, Department of Biochemistry, University of Nairobi, Kenya. Dorington O. Ogoyi, PhD, is an Associate Professor, Department of Biochemistry and Biotechnology, Technical University of Kenya, Nairobi, Kenya. Julie E. Fischer, PhD, is Technical Director for Global Health, CRDF Global, Arlington, VA.

Health Security

|December 8, 2025

Summary

This summary is machine-generated.

Collaborative simulation exercises enhance biosecurity by raising stakeholder awareness of gene synthesis risks. This approach identifies context-specific, multilayered strategies for national and institutional oversight of nucleic acid synthesis.

Keywords:

Biotech industry Dual-use science Gene synthesis Lab safety Select agents Tabletop exercises

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Area of Science:

Biosecurity
Life Sciences
Biotechnology

Background:

Gene synthesis technologies are vital for research and medical countermeasures.
Growing nucleic acid synthesis market raises concerns about misuse of high-consequence pathogens.
International voluntary screening measures exist, but national oversight capacities vary widely.

Purpose of the Study:

To raise stakeholder awareness of biosecurity risks associated with gene synthesis.
To identify context-specific, multilayered biosecurity approaches.
To enhance national and institutional oversight of nucleic acid synthesis procurement.

Main Methods:

Collaborative development of simulation exercises.
Mentored, virtual breakout sessions with international experts.
Leveraging local knowledge to inform biosecurity strategies.

Main Results:

Simulation exercises effectively raised awareness among key stakeholders.
Identified context-specific, sustainable biosecurity measures.
Demonstrated the utility of collaborative exercises for addressing research governance gaps.

Conclusions:

Collaborative simulation exercises are a valuable tool for enhancing biosecurity.
Multilayered, context-specific approaches are crucial for mitigating gene synthesis risks.
The project reinforced the principle of using collaborative exercises to improve national and institutional biosecurity.