Related Experiment Video
Updated: Mar 6, 2026

11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
13.5K
Hazardous Drugs and USP : Implications for Nurses.
1Seattle Cancer Care Alliance.
Clinical Journal of Oncology Nursing
|March 19, 2017
Summary
New USP <800> guidelines mandate stricter handling of hazardous drugs (HDs) for nurses. Compliance with these enforceable standards, including the use of closed-system transfer devices, is crucial for healthcare facilities.
Area of Science:
- Pharmaceutical Sciences
- Nursing Practice
- Public Health
Background:
- Decades-old guidelines for hazardous drug (HD) handling lacked enforceability.
- The U.S. Pharmacopeial Convention's USP <800> chapter introduces expanded, detailed guidelines for HD compounding and administration.
- Unlike previous recommendations, USP <800> will be enforced by state boards of pharmacy.
Purpose of the Study:
- To outline the risks associated with hazardous drugs (HDs).
- To explain the implications of USP <800> for nursing practice.
- To highlight key requirements for nurses under the new USP <800> standards.
Main Methods:
- Review of nursing-specific requirements within USP <800>.
- Discussion of closed-system transfer devices (CSTDs) mandated by USP <800>.
- Analysis of the impact of USP <800> on healthcare facility protocols.
Main Results:
- Healthcare organizations face varying degrees of change to achieve USP <800> compliance.
- Some facilities may already meet USP <800> standards, while others require substantial modifications.
- Implementation of specific safety measures, like CSTDs, is necessary.
Conclusions:
- USP <800> represents a significant advancement in the enforceable safety standards for handling hazardous drugs.
- Nurses must be aware of and adhere to the new requirements to ensure patient and provider safety.
- Proactive adaptation to USP <800> is essential for all healthcare settings managing hazardous drugs.
More Related Videos
Related Concept Videos
Pharmaceutical Poisoning: Potential Scenarios
47
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
47
Factors Affecting Drug Response: Overview
3.2K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
3.2K
Drug Dosing: Geriatric Patients
328
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
328
Drug Toxicity: Risk factors
65
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
65
Pharmacokinetics in Pediatric Patients: Drug Excretion
342
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
342
Drug Regulation
3.2K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
3.2K

