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Published on: September 1, 2015
Network analysis of Urocortins
1Department of Traditional Chinese Medicine, Zhejiang Pharmaceutical College, Ningbo, China.
Objectives:
Urocortins (Ucns), members of corticotropin releasing factor family, play critical roles in a number of pathological and physiological conditions. Many proteins have been reported to participate in Ucns signaling pathways, which formed complex interaction networks.
Methods:
STITCH ('search tool for interactions of chemicals') is an interaction network database that provides exploration of the known and predicted interactions among large sets of chemicals and proteins.
Results:
In this study, using STITCH, interaction networks of Ucns were constructed by database mining, and then their topological parameters and important nodes were analyzed by network related tools. This may help a quick and thorough overview of the Ucns mechanisms underlying in a visual format.
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