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In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
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Novel Insights into Complex Cardiovascular Pathologies using 4D Flow Analysis by Cardiovascular Magnetic Resonance

Adam James Lewandowski1, Betty Raman2, Rajarshi Banerjee3

  • 1Oxford Cardiovascular Clinical Research Facility, John Radcliffe Hospital, OX3 9DU. Oxford. United Kingdom.

Current Pharmaceutical Design
|March 21, 2017
PubMed

Insights

Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) provides non-invasive blood flow assessment. This advanced imaging technique offers new insights into cardiovascular diseases and function.

Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Biomedical Engineering

Background:

  • Accurate blood flow assessment is crucial for understanding cardiovascular disease.
  • Current imaging methods for blood flow quantification are often limited or invasive.

Purpose of the Study:

  • To review the potential of four-dimensional velocity cardiovascular magnetic resonance (4D flow CMR) for non-invasive blood flow assessment.
  • To highlight the applications and future directions of 4D flow CMR in cardiovascular research and clinical practice.

Main Methods:

  • 4D flow CMR utilizes phase contrast imaging with flow encoding in three spatial dimensions and time.
  • This technique allows for comprehensive assessment of blood flow dynamics throughout the cardiovascular system.

Main Results:

  • 4D flow CMR enables non-invasive quantification of flow, pressure, velocity, wall shear stress, and turbulent kinetic energy.
  • It provides novel insights into various cardiovascular pathologies, including cardiomyopathies and aortic diseases.

Conclusions:

  • Standardization of 4D flow CMR acquisition and analysis is necessary for broader clinical adoption.
  • Automated tools and standardized reporting will enhance capacity for large studies and clinical translation.
Abstract

Keywords:
4D flowCMRblood flow.cardiovascularfour-dimensional velocityimagingmagnetic resonance

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