Segmental Vitiligo

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Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Nanja van Geel¹, Reinhart Speeckaert¹

¹Department of Dermatology, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium.

Dermatologic Clinics

|March 21, 2017

Abstract:

Segmental vitiligo is characterized by its early onset, rapid stabilization, and unilateral distribution. Recent evidence suggests that segmental and nonsegmental vitiligo could represent variants of the same disease spectrum. Observational studies with respect to its distribution pattern point to a possible role of cutaneous mosaicism, whereas the original stated dermatomal distribution seems to be a misnomer. Although the exact pathogenic mechanism behind the melanocyte destruction is still unknown, increasing evidence has been published on the autoimmune/inflammatory theory of segmental vitiligo.

Keywords:

Classification Halo nevi Lines of blaschko Mosaicism Segmental Segmental vitiligo Surgical treatment Vitiligo

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