Chemical-Induced Vitiligo

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¹Department of Dermatology, University of Massachusetts Medical School, 364 Plantation Street, LRB 225, Worcester, MA 01605, USA.

Dermatologic Clinics

|March 21, 2017

Abstract:

Chemical-induced depigmentation of the skin has been recognized for more than 75 years, first as an occupational hazard but then extending to those using household commercial products as common as hair dyes. Since their discovery, these chemicals have been used therapeutically in patients with severe vitiligo to depigment their remaining skin and improve their appearance. Because chemical-induced depigmentation is clinically and histologically indistinguishable from nonchemically induced vitiligo, and because these chemicals appear to induce melanocyte autoimmunity, this phenomenon should be known as "chemical-induced vitiligo," rather than less accurate terms that have been previously used.

Keywords:

Autoimmunity Cellular stress Chemical Leukoderma Monobenzone Phenol Rhododendrol Vitiligo

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