Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of reducing fever01:22

Methods of reducing fever

1.5K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.5K
Increased Body Temperature01:25

Increased Body Temperature

7.6K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.6K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

659
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
659
Milgram's Obedience to Authority02:20

Milgram's Obedience to Authority

7.5K
Obedience to authority is classically demonstrated in a more famous series of social psychology experiments performed by Stanley Milgram. He was a social psychology professor at Yale who was influenced by the trial of Adolf Eichmann, a Nazi war criminal. Eichmann’s defense for the atrocities he committed was that he was “just following orders.”
7.5K
Types of Fever01:25

Types of Fever

1.4K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
1.4K
Decreased Body Temperature01:29

Decreased Body Temperature

1.1K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 'DIY' tragedy.

The American journal of medicine·2025
Same author

THE JEREMIAH METZGER LECTURE: THE FIRST QUARTER OF ACCA'S SECOND CENTURY … "WARTS AND ALL".

Transactions of the American Clinical and Climatological Association·2025
Same author

Should end-to-end deep learning replace handcrafted radiomics?

European journal of nuclear medicine and molecular imaging·2025
Same author

Feasibility of an Ultra-Low-Dose PET Scan Protocol with CT-Based and LSO-TX-Based Attenuation Correction Using a Long-Axial-Field-of-View PET/CT Scanner.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Russian riddles Dostoevsky's seizures, Dyspnea and death.

The American journal of the medical sciences·2025
Same author

The Charmed Life of 98.6°F.

The American journal of medicine·2025

Related Experiment Video

Updated: Mar 6, 2026

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.5K

Oliver Cromwell׳s Fatal Ague.

Sanjay Saint1, Thomas Cogswell2, Eliot Siegel3

  • 1The Hospital Outcomes Program of Excellence (HOPE), VA Ann Arbor Healthcare System, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; The Institute for Healthcare Policy and Innovation, University of Michigan Medical School, Ann Arbor, Michigan.

The American Journal of the Medical Sciences
|March 21, 2017
PubMed
Summary

Oliver Cromwell, a prominent British general, died suddenly at age 59 from a complex infection, possibly two acting in concert. His fatal illness, diagnosed as "bastard tertian ague," is re-examined using advanced computational analysis.

Keywords:
EdocarditisEnteric feverMalariaOliver Cromwell

More Related Videos

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

20.2K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.4K

Related Experiment Videos

Last Updated: Mar 6, 2026

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.5K
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

20.2K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.4K

Area of Science:

  • Medical History
  • Infectious Diseases
  • Computational Biology

Background:

  • Oliver Cromwell, Lord Protector of England, Scotland, and Ireland, died suddenly in 1658 at age 59.
  • His death was attributed by contemporary physicians to "bastard tertian ague."
  • Cromwell was a significant military and political figure, known as the "terror of Europe" during his time.

Discussion:

  • Modern analysis of Cromwell's clinical records, utilizing supercomputing resources from the U.S. Department of Energy, provides new insights into his death.
  • The investigation suggests that Cromwell's demise was likely caused by a bacterial or parasitic infection.
  • The possibility of a synergistic effect between two concurrent infections is considered a significant factor.

Key Insights:

  • The fatal illness of Oliver Cromwell, previously diagnosed as "ague," is now strongly suggested to be a complex infection.
  • Advanced computational analysis offers a novel approach to understanding historical medical cases.
  • The findings challenge previous assumptions about the cause of death for this pivotal historical figure.

Outlook:

  • Further computational analysis could illuminate other historical medical mysteries.
  • This interdisciplinary approach combining history and modern science offers a powerful tool for research.
  • Continued investigation into infectious diseases may reveal more about their historical impact.