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Clinical Course and Outcomes of Pediatric Tubercular Uveitis in North India

Savleen Kaur1, Kanika Aggarwal1, Aniruddha Agarwal1

  • 1a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.

Ocular Immunology and Inflammation
|March 21, 2017
PubMed

Insights

Pediatric tubercular (TB) uveitis presents similarly to adult forms but may require more aggressive treatment. Some children show suboptimal response to standard anti-TB therapy, necessitating additional immunosuppression.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Pediatrics

Background:

  • Tubercular uveitis is a significant cause of vision impairment in endemic regions.
  • Understanding pediatric TB uveitis is crucial for timely diagnosis and management.

Purpose of the Study:

  • To analyze clinical features, disease course, management strategies, and outcomes of pediatric tubercular uveitis.
  • To evaluate the efficacy of anti-tubercular therapy (ATT) in children with TB uveitis.

Main Methods:

  • Retrospective review of hospital records for children (≤16 years) diagnosed with TB-associated uveitis.
  • Data collected from a large tertiary-care institute between January 2001 and December 2015.

Main Results:

  • 32 children diagnosed with TB-associated uveitis (mean age 10.7 years).
  • Posterior uveitis and panuveitis were the most common presentations (43.75% each).
  • Nearly 30% of patients had a suboptimal response to ATT and corticosteroids, requiring further immunosuppression.

Conclusions:

  • Tubercular uveitis is an important cause of pediatric uveitis in TB-endemic countries.
  • Clinical manifestations in children mirror those seen in adults with TB-related uveitis.
  • Pediatric TB uveitis may necessitate more aggressive therapeutic approaches, including intensified corticosteroid and immunosuppressive regimens.
Abstract

Keywords:
Extrapulmonary tuberculosisintraocular tuberculosispediatric tuberculosispediatric uveitis

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