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Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway

A Vasconcelos-Dos-Santos1, H F B R Loponte1, N R Mantuano1

  • 1Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, Brazil.

Oncogenesis
|March 21, 2017
PubMed
Summary

High glucose levels in diabetes promote colon cancer growth and spread by altering cell sugar coating. The hexosamine biosynthetic pathway (HBP) links hyperglycemia to cancer malignancy, offering a potential therapeutic target.

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