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The Effect of Montelukast on Mild Persistent OSA after Adenotonsillectomy in Children: A Preliminary Study

Bing Wang1, Jia Liang1

  • 11 Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Pediatric Research Institute of Chongqing Medical University, National Key Disciplinary Areas of Pediatrics, Ministry of Education, Yuzhong District of Chongqing, China.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|March 21, 2017
PubMed

Insights

Montelukast treatment improved obstructive sleep apnea (OSA) symptoms in children post-tonsillectomy and/or adenoidectomy (T&A). This complementary therapy significantly enhanced the apnea-hypopnea index and oxygen saturation levels.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Pharmacology

Background:

  • Obstructive sleep apnea (OSA) is a common condition in children.
  • Tonsillectomy and/or adenoidectomy (T&A) is a primary treatment for pediatric OSA.
  • Persistent OSA after T&A necessitates further therapeutic strategies.

Purpose of the Study:

  • To evaluate the efficacy of montelukast as an add-on therapy for children with persistent OSA following T&A.
  • To assess the impact of montelukast on objective and subjective measures of OSA severity.

Main Methods:

  • A randomized controlled trial involving 58 children with persistent OSA post-T&A.
  • Participants were assigned to either a 12-week montelukast treatment group or a no-treatment control group.
  • Apnea-hypopnea index (AHI), nadir oxyhemoglobin saturation (nadir SpO2), and Pediatric Sleep Questionnaire (PSQ) scores were recorded.

Main Results:

  • No significant differences in AHI, nadir SpO2, or PSQ scores were observed between groups immediately after surgery.
  • After 12 weeks, the montelukast group showed significant improvements in AHI, nadir SpO2, and PSQ scores (P < .001).
  • The no-treatment group exhibited no significant changes over the study period (P > .05).

Conclusions:

  • Montelukast demonstrates significant therapeutic benefits as a complementary treatment for pediatric OSA after T&A.
  • The findings suggest montelukast can effectively improve sleep disturbances in this patient population.
  • Further research may explore long-term outcomes and optimal dosing strategies.

Keywords:
OSAchildrenmontelukast

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