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Updated: Mar 6, 2026
06:24
Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
10.8K
Systems biology solutions for biochemical production challenges
Anne Sofie Lærke Hansen1, Rebecca M Lennen1, Nikolaus Sonnenschein1
1The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs., Lyngby, Denmark.
Current Opinion in Biotechnology
|March 21, 2017
Summary
Developing microbial cell factories for sustainable fuels and chemicals requires advanced systems biology. These methods push boundaries, driving innovation in metabolic engineering and beyond for a biobased future.
Area of Science:
- Biotechnology
- Metabolic Engineering
- Synthetic Biology
Background:
- Accelerated development of microbial cell factories is crucial for a biobased society, utilizing renewable feedstocks for fuels and chemicals.
- High-performance microbial strains often require numerous genetic modifications and operation under demanding conditions.
Purpose of the Study:
- To survey advanced systems biology applications in engineering microbial production strains.
- To highlight innovations in metabolic engineering for biofuels and chemicals.
Main Methods:
- Omics characterization
- Genome-scale metabolic modeling
- Adaptive laboratory evolution
Main Results:
- Systems biology strategies are being pushed to their limits for complex metabolic engineering projects.
- Advanced applications of these methods are enabling the development of superior microbial production strains.
Conclusions:
- Innovative developments in systems biology for metabolic engineering benefit broader scientific fields.
- Continued advancement of systems biology is key to efficient biofuel and biochemical production.
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