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Updated: Mar 6, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
Extracellular Actin in Health and Disease
N P Sudakov1, I V Klimenkov, V A Byvaltsev
1Irkutsk Surgery and Traumatology Research Center, Irkutsk, 664003, Russia. npsudakov@rambler.ru.
Abstract:
This review considers the functions of extracellular actin - cell surface bound, associated with extracellular matrix, or freely circulating. The role of this protein in different pathological processes is analyzed: its toxic effects and involvement in autoimmune diseases as an autoantigen. The extracellular actin clearance system and its role in protection against the negative effects of actin are characterized. Levels of free-circulating actin, anti-actin immunoglobulins, and components of the actin clearance system as prognostic biomarkers for different diseases are reviewed. Experimental approaches to protection against excessive amounts of free-circulating F-actin are discussed.
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