Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.0K
What is the Immune System?01:38

What is the Immune System?

139.4K
Overview
139.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

562
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
562
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
T Cell Types and Functions01:24

T Cell Types and Functions

2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alarming increase in overweight and obesity among Vietnamese school-aged children: a call for quick intervention.

Perspectives in public health·2026
Same author

Operative technique: The use of a flexor retinacular flap to cover an osteophytic hook of hamate post repair of a chronic rupture of the flexor digitorum profundus tendon of the little finger.

JPRAS open·2025
Same author

BENIGN FASCICULATION SYNDROME AMONG HEALTH CARE WORKERS, A SINGLE CENTER STUDY.

Georgian medical news·2025
Same author

Canonical and hierarchical analyses of body measurements in four Nigerian cattle breeds under an extensive management system.

Tropical animal health and production·2025
Same author

Long-term Surgical Outcome of Congenital Pseudarthrosis of the Tibia.

Malaysian orthopaedic journal·2025
Same author

Perioperative Patient Blood Management in Orthopaedics and Traumatology.

Malaysian orthopaedic journal·2025
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
Same journal

Der Internist·2024
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.4K

[The microbiome and autoimmunity].

T Schröder1,2,3, S Ibrahim4

  • 1Institut für Ernährungsmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. torsten.schroeder@uksh.de.

Der Internist
|March 22, 2017
PubMed
Summary
This summary is machine-generated.

The human microbiome influences immune responses and autoimmunity. Understanding microbiome-host interactions is key to developing new diagnostics and therapies for autoimmune diseases.

Keywords:
Arthritis, rheumatoidAutoimmune diseases, skinDiabetes mellitus, type 1Lupus erythematosus, systemicMultiple sclerosis

More Related Videos

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.6K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K

Related Experiment Videos

Last Updated: Mar 6, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.4K
Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.6K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K

Area of Science:

  • Immunology
  • Microbiology
  • Dermatology

Background:

  • The human body hosts diverse commensal microbial communities, collectively termed the microbiome.
  • The microbiome significantly impacts immune processes and health, including autoimmunity.
  • The intestinal and skin mucosa are key sites of microorganism-host interaction.

Purpose of the Study:

  • To review the role of the microbiome in local and systemic immunity.
  • To explore how disturbed microbiome-host interactions contribute to autoimmune diseases.
  • To highlight the potential for microbiome-based diagnostics and therapeutics.

Main Methods:

  • Literature review of existing research on microbiome and immunity.
  • Analysis of studies focusing on intestinal and skin microbiota.
  • Synthesis of evidence linking microbiome dysbiosis to autoimmune conditions.

Main Results:

  • Microbiota composition affects intestinal barrier function and immune modulation.
  • Skin microbiome is crucial for skin barrier integrity and autoimmune skin diseases.
  • Altered microbiome-host interactions are implicated in the development and progression of autoimmunity.

Conclusions:

  • The microbiome plays a critical role in immune system regulation.
  • Dysbiosis can trigger or exacerbate autoimmune diseases.
  • Targeting the microbiome offers promising avenues for autoimmune disease treatment.