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Potentiation of small cell lung cancer-related SIADH by trifluoperazine
M J Kennedy1, R K Shelley, P A Daly
1Department of Haematology/Oncology, St. James's Hospital, Dublin, Ireland.
European Journal of Respiratory Diseases
|November 1, 1987
Abstract:
The syndrome of inappropriate anti-diuretic hormone secretion (SIADH) is a feature of approximately 7% of cases of small cell lung cancer (SCLC). The elaboration of peptide hormones by this tumour is well recognised and cerebral oedema resulting from inappropriate ADH secretion may be a life-threatening complication of this illness, requiring prompt intervention. We report a patient with SCLC who presented with SIADH which worsened abruptly each time he was treated with trifluoperazine for a co-existing psychosis.