Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A complete tear of Achilles tendon caused by a kite string - A case report.

Trauma case reports·2026
Same author

Ankle Malunion: A Systematic Case-Based Approach to Treatment and a Modified Classification.

Indian journal of orthopaedics·2026
Same author

Outcomes of Modified Blair Fusion in Avascular Necrosis Following Talar Fractures.

Indian journal of orthopaedics·2026
Same author

Editorial: Complications of Lower Limb Trauma: The Persistent Challenge in Modern Trauma Care.

Indian journal of orthopaedics·2026
Same author

Global trends and research hotspots in soccer injury literature: A bibliometric analysis (1904-2025).

Journal of ISAKOS : joint disorders & orthopaedic sports medicine·2026
Same author

Soft-tissue Leiomyoma in a Rare Location: The Achilles Tendon.

Journal of orthopaedic case reports·2026

Related Experiment Video

Updated: Mar 6, 2026

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
14:38

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

19.5K

PRP in OA knee - update, current confusions and future options.

Mandeep S Dhillon1, Sandeep Patel1, Rakesh John1

  • 1Department of Orthopaedics, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

SICOT-J
|March 22, 2017
PubMed
Summary

Platelet-rich plasma (PRP) is superior to hyaluronic acid and placebo for early knee osteoarthritis (OA) symptom relief. Enhancing PRP delivery may improve long-term healing and clinical effects.

More Related Videos

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
14:49

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Published on: September 29, 2018

42.5K
A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood
06:10

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

Published on: August 15, 2025

1.5K

Related Experiment Videos

Last Updated: Mar 6, 2026

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
14:38

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

19.5K
Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
14:49

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Published on: September 29, 2018

42.5K
A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood
06:10

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

Published on: August 15, 2025

1.5K

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomaterials

Background:

  • Platelet-rich plasma (PRP) shows consistent positive outcomes in early knee osteoarthritis (OA).
  • Clinical trials indicate PRP's superiority over hyaluronic acid (HA) and placebo for symptomatic treatment of early OA.
  • Current PRP therapy provides short-term growth factor release, with effects waning by year-end.

Purpose of the Study:

  • To review the current evidence on PRP for early knee OA.
  • To address confusions surrounding PRP usage in OA treatment.
  • To explore innovative trends and strategies for improving PRP efficacy in early knee OA.

Main Methods:

  • Review of existing clinical trials and in vitro/animal studies on PRP for early knee OA.
  • Analysis of PRP's growth factor release mechanisms and clinical outcomes.
  • Evaluation of combination therapies involving PRP with biocompatible carriers or HA.

Main Results:

  • PRP consistently outperforms HA and placebo in managing early knee OA symptoms.
  • Short-term growth factor release from PRP limits sustained clinical benefits.
  • Emerging strategies like PRP combined with gelatin hydrogel, chitosan, or HA show promise for enhanced therapeutic effects.

Conclusions:

  • PRP is the leading treatment option for symptomatic relief in early knee OA.
  • Sustained growth factor delivery is crucial for improved biological healing and long-lasting clinical results.
  • Investigating novel PRP formulations and delivery systems is essential for optimizing OA management.