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Isolation of Cardiomyocytes from Fixed Hearts for Immunocytochemistry and Ploidy Analysis
Published on: October 7, 2020
A novel myocardium segmentation approach based on neutrosophic active contour model
Yanhui Guo1, Guo-Qing Du2, Jing-Yi Xue3
1Department of Computer Science, University of Illinois at Springfield, Springfield, IL USA.
This study introduces a new neutrosophic active contour model (NACM) for accurate automatic myocardium detection in echocardiography. The NACM method significantly improves the accuracy of identifying heart muscle boundaries, aiding in diagnosis and treatment planning.
Area of Science:
- Medical Imaging
- Cardiology
- Image Processing
Background:
- Accurate myocardium delineation in echocardiography is crucial for diagnosing heart conditions.
- Challenges include low signal-to-noise ratio, poor contrast, and noise in echocardiographic images.
- Automatic detection can assist radiologists and improve diagnostic accuracy.
Purpose of the Study:
- To develop an automated method for detecting the myocardium region in left ventricle myocardial contrast echocardiography (LVMCE) images.
- To aid radiologists in diagnosing heart problems and measuring infarction size.
- To overcome limitations of existing methods in distinguishing myocardium from surrounding tissues.
Main Methods:
- Images are mapped to a neutrosophic similarity (NS) domain using intensity and homogeneity features.
- A neutrosophic active contour model (NACM) is proposed, with its energy function defined by NS values.
- Clustering algorithms initialize the ventricle region for improved accuracy and speed, followed by curve evolution for endocardium and epicardium detection.
Main Results:
- The NACM method demonstrated superior performance compared to eliminated particle swarm optimization (EPSO) and active contour model without edges (ACMWE).
- NACM achieved significantly lower Hdist and AvgDist metrics for both endocardium and epicardium detection.
- For endocardium, NACM resulted in Hdist of 4.55 ± 0.9mm and AvgDist of 0.58 ± 0.18mm, outperforming EPSO and ACMWE.
Conclusions:
- The proposed NACM method accurately detects myocardium in LVMCE images.
- This automated approach is valuable for clinical applications, particularly for measuring myocardial perfusion and infarct size.
- The method offers a significant improvement over existing techniques for cardiac image analysis.
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