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Effects of chronic prednisolone treatment on postjunctional membrane responses to agonist
1Department of Physiology, Columbia University, New York, NY.
Abstract:
Using frogs treated 1 month with prednisolone, we studied responses of the muscle postjunctional membrane to acetylcholine and carbamylcholine. In control muscles following a bath application of 3 microM neostigmine or 30 microM pyridostigmine, there was an increased depolarization response to iontophoretically applied acetylcholine or carbamylcholine. Results with prednisolone-treated frog muscle were essentially identical. In some fibers of prednisolone-treated muscle there was a decrementing response to repetitive iontophoretic application of carbamylcholine. Prolonged administration of prednisolone may accelerate desensitization of acetylcholine receptors during repetitive application of agonist.
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