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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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Related Experiment Video

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Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
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Exosomes in Critical Illness.

Nora Terrasini1, Vincenzo Lionetti

  • 11Laboratory of Translational Critical Care Medicine (TRANCRILAB), Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy. 2U.O.S Anesthesiology and Intensive Care Medicine, Fondazione Toscana "G. Monasterio," Pisa, Italy.

Critical Care Medicine
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Summary
This summary is machine-generated.

Exosomes, tiny vesicles involved in cell communication, show promise for diagnosing and treating critical illnesses. Their levels and functions are key to understanding organ injury and developing personalized nanomedicine therapies.

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Area of Science:

  • Cellular Biology
  • Nanomedicine
  • Critical Care Medicine

Background:

  • Exosomes are nanoscale vesicles involved in intercellular communication.
  • They play a role in maintaining tissue homeostasis.
  • Exosomes are emerging as theranostic tools for assessing organ response to injury and treatment.

Purpose of the Study:

  • To review current insights into the role of exosomes in managing injury and repair responses in critical illness.
  • To explore the potential of exosomes in personalized medicine for critical care.

Main Methods:

  • Literature search of PubMed using "related articles" methodology.
  • Inclusion of original articles, review articles, and conference proceedings.
  • Detailed review and summarization of relevant pre-clinical and clinical studies.

Main Results:

  • Exosome biogenesis, characterization, and function in critical illness.
  • The role of exosomes in acute lung, cardiac, and kidney injury.
  • Exosomes in sepsis, limitations in isolation, and theranostic perspectives.

Conclusions:

  • Circulating exosome levels correlate with critical illness onset and progression.
  • Exosomes from different cell phenotypes have distinct protective functions.
  • Multifunctional exosomes offer potential for personalized nanomedicine in critical illness.