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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Dermis
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Elastin is Responsible for Tissue Elasticity01:12

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
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Elastólisis de la dermis media diseminada.

María Pousa-Martínez1, Carlos Aliste, Hugo Vázquez-Veiga

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Mid-dermal elastolysis (MDE) is a rare skin condition causing elastic fiber loss. This report details a patient with a widespread form of MDE, contributing to understanding its varied presentation.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Mid-dermal elastolysis (MDE) is an uncommon dermatological disorder.
  • Characterized by the loss of elastic fibers specifically in the mid-dermis.
  • The exact cause (pathogenesis) of MDE remains largely unknown.

Observation:

  • MDE typically affects the neck, trunk, and upper limbs.
  • Three distinct clinical presentations exist: fine wrinkles, perifollicular papules, and reticular erythema.
  • This case involves a patient presenting with a disseminated form of MDE.

Findings:

  • The report focuses on a patient exhibiting a widespread presentation of MDE.
  • This disseminated form expands the known clinical spectrum of the disorder.
  • Further investigation into this patient's MDE is warranted.

Implications:

  • This case contributes to the limited understanding of MDE's clinical variations.
  • Reporting disseminated MDE may aid in earlier diagnosis and treatment.
  • Further research into MDE pathogenesis and diverse presentations is crucial.