Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.4K
Pleiotropy01:33

Pleiotropy

43.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.7K
Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

4.9K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
4.9K
Papillary Dermis01:11

Papillary Dermis

6.4K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.4K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.9K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subclinical Venous Injury in Transvenous Lead Extraction: Histological Correlation With Clinical Risk Factors.

Journal of cardiovascular electrophysiologyยท2026
Same author

Involvement of the external ear by inflammatory skin diseases.

Clinics in dermatologyยท2026
Same author

Benign tumors of the auricle and the external auditory canal.

Clinics in dermatologyยท2026
Same author

Cardiac sarcoidosis presenting as sustained ventricular tachycardia mimicking arrhythmogenic right ventricular cardiomyopathy.

HeartRhythm case reportsยท2026
Same author

Management of Lead-Related Superior Vena Cava Syndrome: Clinical and Procedural Outcomes.

JACC. Clinical electrophysiologyยท2026
Same author

Knowledge gaps and educational needs in the perioperative management of genetic arrhythmia syndromes: a survey of the American Society of Anesthesiologists.

British journal of anaesthesiaยท2025

Related Experiment Video

Updated: Mar 5, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.9K

Extensive unilateral nevus comedonicus without genetic abnormality.

Anca Chiriac1, Luminita Paduraru, Gorduza Vlad Eusebiu

  • 1Apollonia University. Nicolina Medical Center, Dept.of Dermatology , Iasi, Romania. ancachiriac@yahoo.com.

Dermatology Online Journal
|March 23, 2017
PubMed
Summary

Nevus comedonicus, a rare genodermatosis, presents as dilated pores with keratin plugs. This case highlights a severe, unilateral presentation in a young girl, later spreading bilaterally.

More Related Videos

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

3.0K

Related Experiment Videos

Last Updated: Mar 5, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.9K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

3.0K

Area of Science:

  • Dermatology
  • Genetics
  • Pediatrics

Background:

  • Nevus comedonicus is a rare genodermatosis.
  • Characterized by unilateral distribution of dilated pilosebaceous orifices filled with keratin plugs.
  • Lesions typically appear at birth or before age 10.

Observation:

  • A severe form of nevus comedonicus was observed in a 2.7-year-old girl.
  • Initial lesions were unilateral, linear, and followed Blaschko lines on the left side.
  • Progressive development of lesions occurred on the right scalp and left gluteal area.

Findings:

  • The case demonstrates a severe and progressing presentation of nevus comedonicus.
  • The Blaschko line distribution suggests a mosaic genetic pattern.
  • Bilateral spread occurred despite initial unilateral presentation.

Implications:

  • This case expands understanding of nevus comedonicus severity and progression.
  • Highlights the importance of monitoring for lesion spread and potential bilateral involvement.
  • Informs genetic counseling and management strategies for this genodermatosis.