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Updated: Mar 5, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Claiming the validity of scientific evidence in post-truth times
Diego J Martino1,2,3, Cecilia Samamé4,5, Sergio A Strejilevich4,6
1Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Gurruchaga 2463, 1º C, 1425, Buenos Aires, Argentina. diejmartino@gmail.com.
Abstract:
This letter is written in response to a review recently published in the journal. The aim is to highlight a potential methodological limitation common to many studies comparing bipolar patients with few previous episodes versus those with multiple episodes, and in which the results are interpreted as indicating the longitudinal course of the illness.
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