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Related Experiment Video

Updated: Mar 5, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Topical Metered-dosing Dispenser Performance Evaluation.

Qiang Liu¹, Thomas C Kupiec¹, Nicole T Vu²

¹Analytical Research Laboratories Inc., Oklahoma City, Oklahoma.

International Journal of Pharmaceutical Compounding

|March 24, 2017

Summary

This summary is machine-generated.

Topical metered-dosing dispensers ensure accurate medication delivery. The Topi-CLICK dispenser demonstrated superior precision and accuracy compared to airless pumps, performing consistently across various cream bases without needing recalibration.

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Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
Dermatology

Background:

Topical metered-dosing dispensers are crucial for patient adherence and product integrity.
Evaluating dispenser performance with diverse cream formulations is essential for clinical application.

Purpose of the Study:

To assess the accuracy, precision, and residual output of topical metered-dosing dispensers.
To compare the performance of different dispenser types using various topical cream bases.

Main Methods:

Five distinct dispenser types were tested in triplicate.
Three commercial topical cream bases with varying properties were utilized.
Dispensing accuracy and precision were evaluated over 60 doses (0.5 mL each) totaling 30 mL capacity.

Main Results:

The Topi-CLICK dispenser exhibited the highest precision and accuracy in dosing.
Airless-pump dispensers showed significant variability in dispensing, potentially requiring product-specific calibration.
Topi-CLICK's performance remained consistent regardless of the cream base used, eliminating the need for recalibration.

Conclusions:

Topi-CLICK offers superior dosing accuracy and precision for topical creams compared to airless pump dispensers.
The consistent performance of Topi-CLICK across different formulations simplifies its use and enhances patient reliability.